Bone fractures. Early research suggests that applying a specific Cissus quadrangularis product (Calzbone, Verdure Sciences) to the skin improves fracture healing in some people. It is unclear is the effects of this product are due to Cissus quadrangularis or the other ingredients in this product, which include calcium, vitamin D, and boswelia. Other research shows that taking a different Cissus quadrangularis combination product that also contains ashwagandha and holy basil for 6 months improves bone mineral density (BMD) in some people. Whether this increase in BMD reduces the chance for fractures is not known.